I think there's bound to be a joke about going from an 8 3/8" .44 magnum when you are 25 to a 2" .38 when you are 65...
I'm 61, and so far, I haven't been afflicted with arthritis or other issues that would make me switch from my preferred 1911s or M&Ps to a lighter caliber semi or revolver, thank goodness. My eyesight has actually improved thanks to cataract surgery. I know I don't currently have the full body strength that I once had, and I'm sure the day will come when I too will change my carry gun based on necessity, and not preference.