If I had to make that choice it would be my Model 686 Plus Mountain Gun. Anywhere in the USA where I might have to "head for the hills", I should be able to find .38/.357 ammunition. I don't need magazines...whatever I can stuff into the 7-shot cylinder will function, from .38 wadcutters to the hottest .357 JHP; I can even use shot loads. The rear sight is adjustable, the stainless steel construction will resist corrosion and it's plenty accurate. I can use it on most 4 and 2-legged critters...the only thing I might do is take off the wood grips and re-install the Hogue rubber grips it came with, as they will be harder to damage and help in the recoil/muzzle-flip taming department.
I'm with this guy.
Plus I love that gun.