Personally, I really like having a handgun and a rifle in the same caliber. On pack trips with the pack string, my sidearm is normally my Ruger Blackhawk in .45 Colt. It's companion, my truck gun, is a Rossi Model 1892 in .45 Colt.
View attachment 756242
View attachment 756239
I also have a Marlin 1894 in .38 special/.357 magnum that I pair with my Smith and Wesson Model 27-2. Do I plan on any long-range hunting with those rifles? Nope. But they're handy to carry and I don't have to be packing two different calibers of ammo.