Got both, like both, but very different guns
I've got a Ruger New Model Single-Six that I bought in the mid-Seventies and a barn find (long story) 1947-vintage K-22. Clearly the K-22 is the more valuable of the two. The Ruger came with the .22 Mag extra cylinder, so clearly it will do something the K-22 can't, at least not without spending a fortune to have somebody hand-fit a Mod. 18 cylinder to it, incidentally bubba-smithing a classic S&W. Not going there, especially as I doubt I've actually put a full box of magnums through the Ruger in the 40-plus years I've owned it.
I don't really understand the 3-screw snobs in the Ruger crowd, except perhaps purely from the collector value standpoint. Being able to safely carry only five rounds in a six-shooter is a definite minus for a field gun, in my view. The one-way cylinder rotation is a nuisance, and I've cussed mine from time to time. Eventually it may bother me enough to make me order the Power Custom free-spin pawl, or maybe the entire half-cock hammer/trigger kit, and spend the time to fit it, but so far I just swear at it and live with it.
My one real gripe with the Ruger is that the cylinder bores have sufficient rough machining marks in the chamber throat area that soft, unplated bullets of some brands leave lead behind, so much that after a couple dozen rounds it becomes nearly impossible to get a new round in the chamber. A gunsmith friend tells me that's not uncommon with the brand, and he's suggested very careful polishing to cure the problem. I'll probably do that before I spring for the after-market lockwork.