I used to carry them in my Model 60 when I was stationed on Guam. I was an Air Force SP so I had to carry my trusty Model 15 with PGU ball on duty but also I had a Guam concealed weapon permit. The Chief's Special was my constant companion off duty, and sometimes found its way into my bag at work.
One midnight shift the LE flight chief and I grabbed the key to the range and headed out to shoot toads. Guam toads come out at night in huge numbers. They are big fat monsters and are unavoidable on the roads, which are made of crushed coral and slippery anyway and even moreso with a layer of popped toads on them. After a rain the paved parts of the range would be awash in toads.
We had some PGU ball with us so we swapped out our mildewed issued rounds with shiny new ones and commenced firing. After awhile the flight chief said - LT, don't you think the range guys are gonna be suspicious of all these pistol-shot toads?
I conceded his point, but decided to try out my Model 60 and its Nyclads on a few toads. It was impressive. Where most of the FMJ victims just rolled over, the ones hit with Nyclads blew open with style.
I saved the last one for a coconut hanging about ten feet up a tree. I got it dead center and it hit the ground bleeding milk profusely. I pried it open and the Nyclad was still inside, perfectly expanded. I was impressed.
We reloaded with the old rounds so as to allay suspicion on turn-in. No one complained of the shot-up toads.
I'm not sure how it works on people, but for toads and coconuts it was first-rate.