H-110 (Same powder as Win-296) is a poor choice for less than full power loads in the 45c, or .357 mag. for that matter. This powder needs high pressure and a firm crimp to burn properly. It does not do well with reduced loads.
Larry
I keep seeing this claim about H110 and have come to the conclusion that there is a lot of Internet Lore (myth) in this claim. The reason is very simple, there is a
WIDE spread of charge weight published loads for this powder in 357 Magnum if you compare multiple sources.
As an example, for the Hornady 158 grain Hornady XTP, Hornady lists a starting charge weight of 12.7 grains and a maximum charge weight of 15.6 grains. Look at Hodgdon's data for this exact same bullet and you'll find a starting charge weight of 15.0 grains and a maximum charge weight of 16.7 grains,
a weight 4 full grains heavier than Hornady's starting charge weight. This is about a 25% difference in charge weight between two trusted sources for reloading data.
Note, in my 1892 Winchester I've found 14.8 grains of H110 with the 158 grain XTP produces the best accuracy and over a chronograph the average variation in velocity was just 7 fps. in a 5 shot string. So, either H110 is more tolerant of sub maximum charge weights than these internet claims or Hodgdon's data is well over the SAAMI maximum pressure for the 357 Magnum. My hunch is that H110 is actually very tolerant at less than maximum charge weights as long as a Magnum primer is used to provide ignition. I will also note that while their charge weights could be regarded by some as overly conservative, in 357 Magnum, 300 Blackout, and 223 Remington I have found my most accurate loads using the Hornady 9th edition.
Ivan, I would suggest that you do some testing to insure your primers are fully seated, because I suspect that this may be a large factor in your issue. BTW, as someone who has actually worn out an RCBS handprimer to the point where it wasn't seating primers fully I have first hand experience with what happens. In my case semi auto calibers worked just fine but double action revolver loads started exhibiting misfires.
Testing for this is really really simple, just hit the misfires a second time and see if they fire. If you find that 100% will fire on the second strike IMO your problem is primers that aren't fully seated. If you still have some misfires then you may want to try replacing the strain screw for your 460V. BTW I have also found that the Stainless Steel strain screws will peen over at the tip a lot faster than the blued steel strain screws. When this happens you not onle see a sharp ridge of peened steel form around the tip that makes removal difficult but after 2000-3000 rounds downrange I was starting to see misfire issues. For me it was enough of a problem that I have now replaced the stainless strain screws in my model 620, 625, 617, 610, and 67 revolvers with blued steel versions just so I didn't have to deburr the tip of the strain screw every 4th cleaning.
Yeah, I have a bit of a "thing" for stainless S&W's. In my defense I do have a blued model 19-3 and a blued Dan Wesson 15-2.