I've never shot one. Is the kick any worse than a 12ga slug? Or a 10ga buckshot load?
Well, I've shot 30-06, .308 and 12 ga slugs, and didn't mind a full range session with any of them.
Like
Tom S. anecdote above, about 35 years ago, I fired one round of .458 Win through a Model 70 Safari, and never again, unless I'm facing a charging elephant. Here are some numbers for comparison:
cartridge........gun wt...recoil energy ft-lb...recoil velocity fps
12ga slug.........7.5.........28.8....................?
.308 150gr.........7..........15.8....................11.7
30-06 150gr.......8..........17.6....................11.9
.458 Win 500gr...9..........62.3....................21.1
Recoil energy is how hard your shoulder gets pushed, and recoil velocity is a measure of how fast it happens.
The .458 recoil sensation is double to 2 to4 times as hard and twice as fast as most of us are used to.
I suspect if you were so brave as to shoot a box of .458 Win through a Winchester 70 Safari, you'd have a headache, a bruised shoulder and maybe a detached retina.
A heavier rifle would ameliorate that a bit.