I picked up an RPR recently in .243 Winchester.
Going to use it as a heavy caliber long range varmint rifle. The .243 has some advantages over the 6.5 Creedmoor and .308 for this, at least out to 800 to 1000 yards, depending on bullet weight.
Have not shot it yet. Having some scope issues. The ocular won't adjust far enough back for my changing eyes. Sending it to Leupold. Was only going to use this scope this year, but may wind up having to get a dedicated scope sooner.
This is definitely not a walkabout rifle. This is a position rifle. With the scope, suppressor, mag and bipod, but no ammo, it weighs 14.8 lbs. Length with suppressor is 55".
Some owners are reporting handloads under .2 MOA with the .243 RPR.
The RPR is easily rebarreled. Several aftermarket companies are offering replacement barrels already in a variety of caliber, length and weight options. One of these is .22-250 and .22-250AI. Considering getting another RPR eventually and rebarreling it to .22-250 with a fast twist for 55gr and up for general varmint use, and saving the take off .243 barrel as a spare. The 22-250 should have three to four times the barrel life of the 243, and given the cost of aftermarket barrels (Ruger is not offering replacements, at least at this time) it makes economic sense from a varminting standpoint. Or maybe I'll go 22-250 to start and set up a 243 later.