Absolutely. If I am stuck in a dark alley I would much like a 45 ACP than 9mm. I use a variety of 9mm in IDPA competition to keep cost down and minimize muzzle flip. If I compare my 1911 with winchester brown box, they really do pack a wallop. I know mass times speed could be equating the same kinetic energy. But I have to assume the larger mass bullet is going to transfer it a whole lot better.
Actually energy (kinetic) is mass times velocity squared (momentum is mass times velocity). As such, energy calculations favor higher velocity. This is why a 230 grain .45 ACP and a 115 grain 9mm often have similar energies despite the .45 having twice the mass.
Energy transfer to the target is a function of a number of variables including bullet design. But, generally, energy in and of itself is not a great predictor of incapacitation potential.
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