After 44 years of reloading I've found you can cover almost all the bases for handgun reloading with only three powders. To do this you need a fast powder, a medium powder, and a slow one. In the fast category Bullseye or HP38/WW231, in the medium category Unique or Universal Clays, and in the slow category Alliant 2400 or H110/WW296. Bullseye is a bit faster than HP38/WW231, thus I think it is the better choice for a fast powder since it will do things on the fast side that HP38/WW231 can't do quite as well, and there is overlap between the capabilities of HP38/WW231 and Unique or Universal Clays. On the slow end of things you will get more power with H110/WW296 than you will with 2400. In the medium powders I've always preferred Unique simply because I grew up with it. Also, unlike others, I've found Unique to be cleaner burning than Universal Clays in lighter loads, though I think it burns cleaner than Unique with heavier loads. Therefore my choice, if limited to only three powders, is Bullseye, Unique, and H110/WW296.