Back during the '13 22 LR shortage, I read where a guy figured out that he could buy 22 powder loads ( for Ramshot nail setters). Then put a 22 caliber pellet in the chamber of a 22 single shot, followed by the powder shot, and kill a squirrel for dinner.
Made sense I guess, if one was desperate. I never was, nor did I build up enough nerve to try it. I figure it would foul a barrel pretty quickly. Desperate people do desperate things in desperate times.