I will respectfully disagree. Just because the manuf hasn't bothered to test a given powder/bullet combo does NOT mean it is unsafe, just untested. Just about any powder can be used to some extent in any caliber. It just requires some extrapolation. Not for beginners, but many of us do wildcat reloading, no data, so we extrapolate all the time.
For the 500, the only rifle powder that are likely to give any useful results are the uberfast rifle powders at the beginning of the burn rate chart for rifle powders. That would be AA1680 or maybe RL7 & 4198. After all, these do fine in the lower pressure 45-70, rifle or handgun. Anything slower isn't going to do much but burn a lot of powder. Use 4227 data & work it up in 2/10gr increments. Of course, YOU ASSUME ALL LIABILITY for any load development you do but that is how I would approach it.
I wouldn't press my luck with something like 7828, a fav of mine for over bore rifle rounds, but you are tempting a hangfire or sim with a powder that slow in a large bore. It could go bang for sure, but the results would be poor. Of course you only have to answer to yourself. Many have experimented with such things just because. It we survive, it becomes a learning experience. BE safe.