My first Magnum was a 6" Model 28. That was back in about 1978. I used it as a concealed carry gun and loaded it with Speer .357 140 grain JHP factory loads. I subscribed to the theory that a single torso hit from a .357 would stop the fight consistently. I've owned other .357s and a couple of .41 Magnums along the way.
Over the years I've come to see all handgun cartridges as having only marginal power. I now see a greater need for getting good multiple hits on vital areas(brain, spine, heart, lungs, etc) of the threat quickly while shooting two-hand, strong hand only, or weak hand only, with a load that penetrates deeply enough and expands consistently. My anticipated targets are wild dogs and 2-legged predators, so I don't worry about dealing with bears or other larger animals.
I only have one Magnum now, a .357 (649-5), and I load it with CorBon .38 +P 110 grain DPX. I prefer .38 +P as a fighting load because of its lower blast and flash, and faster shot to shot recovery, relative to .357 loads. I also use the same load in my 642-2s. I can't remember the last time I fired any .357 loads or even had any onhand; it's been a decade or more. I typically train with various +P .38 FMJ/TMJ loads.
Specifically i choose .38 +P loads that provide sufficient penetration and reliable expansion in ballistic gelatin, according to FBI and IWBA standards. As far as I know, in 2" barrels, only the aforementioned CorBon load, some lots of Speer's 135 gr Short Barrel Gold Dot, Hornady's Critical Defense loads in std pressure and +P, and Winchester's 130 gr +P bonded load meet these requirements consistently.
I don't see the somewhat greater terminal ballistic effects of a .357 load as being worth the greater blast, flash, and recovery time between shots. It is a tradeoff, and other folks will arrive at different conclusions from me.