I've been loading for the last 46 years and have seen almost anything happen. I agree that True Blue may not be the best choice for the 45 ACP. It's very close to BlueDot(as it name implies) and is really too slow for the 45 ACP. I've settled on TiteGroup for my 45 loading, correct burn rate, a little goes a long ways, and it meters well, not to mention it comes in 8# jugs. In your case the bullet would not have gone down the barrel if the primer had not worked at all. It sounds like a less than perfect primer or a slow burning powder that the primer can't ignite properly. Unfortunately, one can't just walk in and buy any powder he wants these days. Other classic powders for the .45 are Bullseye, RED Dot, AA2 and AA5, 231, Unique, and others. As stated, the 45 was originally loaded with Bullseye in 1905. BTW, a digital scale is ideal for checking which loads have powder and which ones don't. Bob!!