I've hunted just about everyrthing 'BIG GAME" in NA with the exception of Brown/Grizz, Polar Bear and Ox. The largest caliber I have used in NA is 338 Wby Mag. For White Tail, Mules, 'Lopes, cats of all varieties I use either a Browning A Bolt or X Bolt in 270 Win (Favorite Caliber) or 30-06, all three loaded with Trophy Bonded bullets. It works for me, but I am comfortable taking a shot out to 400 - 600 yards and regularly practice out to those ramges. Big cats have been taken with as small a caliber as 204 Ruger (that I know of). I have taken game up to and including mule deer with the following, 308 Win, 303 Brit., 6.5 x 55 Swedish, 30/30, 270 Win, 30-06 Spr, 300 Wby Mag and 338 Wby Mag. My elk have been with 30-06 220 gr and the moose I took was with a 338 WM. Shoot what you shoot well and don't worry what someone else is shooting/what the "EXPERTS" shoot, within reason.
Class III