In my personal 380s I use 95 grain powder costed lead RNs for practice/training/target/plinking and I rely on Hornady Critical Defense for worst case scenario use.
I haven't personally tested the Critical Defense for expansion or penetration, but I have read read enough reviews from people that I trust that allow me to put some measure of faith in the ammo. Having said that, a 380 is NOT a primary carry gun for me, but a backup to a backup, so take my opinion on defense ammo with that in mind.
TRE