I bought a new .45 Colt Trapper (no safety, a real big deal to some gun grumblers but I've never figured out why) about 35 years ago. I used only cast bullets in it and fired it regularly. It was quite accurate with the heavy Lyman #454424 bullet, but shot light bullets poorly. I finally lost all interest in the cartridge, much preferring the .44 Special. Sold the Trapper and my S&W 25-5s a few years ago.
I was never sure what such a gun would be good for, but it was fun to shoot if that counts, at least for about thirty years.