OK. I'll deviate slightly. I have an M&P 22 and a Sig Mosquito. I shoot the M&P mostly but to be honest, I wouldn't flip a coin for the difference. I have a bunch of M&Ps and that's the only SIG I own so far, but I'm looking hard at the P250 platform because it's so versatile and I've been so pleased with my Mosquito.
Just letting you know there are other choices. You can't go wrong with either one, IMO.
If I had to let one go, I guess it would be the Mosquito, but mostly because of my unending loyalty to S&W.