Yes.
Well, you said keep it simple!
Okay, let's see what I keep loaded... a 296 with five 200gr Gold Dot JHPs in .44 Special from GA Arms. A 2" 10, 4" 64, and 642, all sporting Remington R38S12 +P .38 Special 158gr LHPSWC's.
The 296 & 642 are CCW's that do double duty. The 10 & 64 are real HD firearms, easily accessible to both my wife and myself. I wanted a 327NG for a 8x load of those same Remingtons.
Now, that isn't all - I keep speedloaders/moonclips loaded for HD for everything in the safe. 629's have similar .44 Specials while .357M's have the same Remington +P .38's. You see my confusion re 'which' caliber - except these are in my safe! So, I guess I am in the .38 camp for easily accessed, ie, when weird noises wake me in the night, protection. Also at hand are a charged cell phone and a bright flashlight.
Stainz