You are starting off with an assumption that the 45 colt is popular. I guess it is in some circles especially on this forum.
There is a governor 2.75" barrel 45 colt, 45acp and 410. Not exactly an ideal carry gun, but can be done.
The only 5 shot 45 colt I've ever seen was a Taurus model 450 in 2" barrel in total titanium, ultra lite and all stainless steel. From what I've heard people that have them, really like them.
To directly answer your question. Yes I'm sure there would be interest. Although I prefer the 45acp in a short barrel revolver.
Dave