The back strap on the Model 645, just as is that of the 39/x39/59/x59 pistols, is aluminum.
I have not one, but two Model 645's. One is a former LEO pistol and shows it, that's the shooter. The other is in excellent condition, appears to have been used very little and was well cared for, that's my Sonny Crockett show piece.
The big S&W pistols are overbuilt for the 45 ACP and will live happily ever after on a diet of 45 ACP +P, if that's your thing. They tend to be at least service grade accurate, 4-6 inches at 25 yards, some do much better. They are also reliable, so long as the magazine is in good condition. They do have a reputation for being so reliable that you can chamber resized empty case from the magazine.