More recent models chambered for the 45 ACp cartridge may not properly chamber the cartridge as the cylinders are bored through with no "step".
The only S&W models that are bored straight through would be the Governor as they also shoot the .45 Colt cartridge and the 410 shotgun round. Some of the Colt 1917's were bored straight through, but AFAIK, all 25's, 625's and 325's - whether ACP or Colt - have a shoulder in the chamber at the beginning of the throat.
Here is my take on the use of moon clips:
There may be people that tell you that you can use your rimless cartridge moon clip gun without moon clips. They will claim that the round will headspace on the shoulder in the chamber, theoretically, they are correct. However, since SAAMI sets the specs for cartridge dimensions, the shoulder is placed at maximum case length depth for a given caliber. My experience has been that any factory ammo or brass, when new, is always considerably less than this dimension - meaning that, in reality, headspacing on that shoulder, by the case mouth, seldom actually occurs.
This is more common with newer .45 ACP guns with SAAMI-spec chambers. While SAAMI has been around since 1926 and the .45 ACP was adopted in its current form in 1911, the SAAMI chamber dimension drawings weren’t done until 1979. So it is quite possible that early .45 ACP revolvers may be more likely to function without clips with a higher rate of reliability, than guns made post-1979, as chamber dimensions were at the discretion of the manufacturer.
What does happen is that variances in chamber roundness, smoothness, cleanliness and other variables, will hold some cartridges firmly enough that a firing pin strike will ignite the primers. Others are driven forward in the chamber, which results in a light primer strike and a failure to ignite.
Just as some rounds are held tightly enough for ignition and others are driven forward, some cases may drop out of the cylinder from gravity, while others may be "pluckable" and yet others will have to be poked out using a rod.
You should consider moon clips essential for any revolver that is chambered for a rimless or semi-rimmed round. The other alternative is using the rimmed version of that round, if one exists.
Moon clips are the greatest thing since sliced bread and people’s aversion to them is, most likely, founded in falsehoods found on the Internet or from people who either have no personal experience, or just a passing experience with them. In order to fully utilize, and fully enjoy, them requires the right tool(s) to load and unload the clips.
Adios,
Pizza Bob