I did the Cologuard and it came back positive. My doctor told me that IHHO there were too many false positives and negatives and to just have the regular old colonoscopy, and get it done with, so I did. I had (they thought) one very large polyp and it was removed. There's a followup done six months later to check to make sure the original polyp was gone. It was, but they found a largish "flat" polyp, and that had be be done by another doctor, who was the "Flat polyp guy". Great. On top of that, my colon is about a foot longer than normal, and the end if it can't be seen with a regular colonoscopy, so I had to have a "Virtual" one, which is drinking some sort of contrast solution, and having an MRI. Oh, that includes them shooting air into your colon. It wasn't pleasant, I would have preferred to be asleep. Not pain from the air, I kept telling them that, I had back and neck pain from the positions I was in on the table. That turned out to involve a scare that wasn't necessary at all. They said in the results that they found a cyst on one of my kidneys that needed to be followed up on. They didn't mention this at all! I was pretty worried over the weekend and I called the doctor Monday morning, and asked about why they hadn't said anything. "Oh, you had that cyst over 12 years ago, and it was the same size, so we aren't worried about it!". I never knew about it, but they showed me it was mentioned in a file folder of stuff that another doctor had sent them. In that file, it mentioned the damn thing had been there since I was about 14! Six months later, I had my fifth prep and 4th "real" colonoscopy and I was due again about the time Covid hit. It looks like my hip replacement will come after another real and virtual scopings. Wonderful..