Only if you are in bed with your diesel mechanic........ the 6.0 is a motor infested with problems.
We have 3 of the V10's at our shop, from 70K to 190K. Pretty solid motors. They do use a little oil, but no more than say a Chevy big block. They wash their sins in gasoline..... and they tend to sin a lot from what I can tell.

We have had some issues with a bad injector, and the aforementioned spark plugs. Them last 2 plugs are NOT fun to change out. They are back there and clearance is scant. Be VERY careful pulling them if they are the original plugs. Hilarity does not ensue if you crack one apart in the back. We have a small exhaust leak on one when cold, but it goes mute when the motor is warm, so we have not changed the gasket.
We have seen the code for a cylinder bank low performance/ cylinder bank lean condition; these tend to be a couple of possible issues: 3 out of 5 times it's a dirty MAF. (We run silty pipeline areas, so the air filters take quite a beating on our jobsites.) The other issues have been a bad plug, and a bad injector. When that code comes up, the thing will use fuel at a rate only equaled by a WWII battleship.
All in all, a pretty good motor. Better dependability than the 6.0 diesel, though the diesel does pull a little better with a heavy load. Better endurance than the 5.4 Tritons we have. Those motors tend to have big end bearing failures, with regularity unfortunately.