The .45 ACP is one of the most devastating manstoppers ever devised. .45 ball put more men in the grave than anything else in WW2 methinks.
Carry with confidence.
Were you there? Even if so, a few personal experiences makes for a very small, statistically insignificant, sampling.
As I recall reading, the GI .45 ball loads were found to be wanting when it came to consistently penetrating, with reliable wounding effect,
heavy winter clothing, as reported in some records from the Korean conflict. I had a friend who did a lot of tunnel rat duty in 'Nam, and while he liked the 1911, he certainly acknowledged that .38 Spl revolvers worked about as well in many close range encounters. Still a pretty small sampling.
Once you learn of actual shootings where more than 25 rounds of either 9mm & .45 ACP JHP's (different shootings) were required to "stop" attackers, and yet single rounds of .25's & .380's "stopped" other attackers ... and direct COM hits from an occasional .308 & 12-ga slug either did, or didn't, make for immediate stops ... and 5-6 rounds of Magnum revolver loads didn't immediately stop an attacker's volitional deadly force actions ... it all sort of blends into background noise.
There's a reason it's not unusual to find LE qual courses-of-fire which involve making accurate shot strings of 2-6 rounds with 12-ga pump guns. Even single threat targets are often designated to receive 2 or more timed hits for a lot of different drills. Controllability and being able to make more than a single accurate hit, if needed, using a 12-ga.
So, when it comes to any of the commonly used defensive/duty handguns, it's still just a
handgun cartridge, meaning it doesn't rise to the level of the power found in centerfire rifles and shotgun buckshot/slugs, which aren't themselves "guaranteed" to provide for immediate incapacitation in any & all circumstances.
I used to carry mostly .45 ACP, .357 Magnum & .44 Magnum for off-duty weapons as young cop. Enough years in the business, much of which was also spent as a firearms instructor & armorer, and nowadays I focus more attention on skillset, mindset & equipment maintenance ... and less on "caliber performance" considerations.
I became much more comfortable carrying .38's & 9's (in comparison to my .40's & .45's) ... and my large .357's, .44's (Mag & Spl) & .45 Colt revolvers haven't seen more than range use for a long time. (I still have a SP101DAO .357 that I like, but it's heavy enough to mostly be a belt gun.) I even picked up a .380 after more than 25 years of not having been willing to carry one (mostly for the reliability issues of many older designs, or their large size in relation to good quality 9's).
It's still just a handgun.