The cylinder release thmbpiece is connected to a drawbar that pushes the cylinder center pin in to free the cylinder for opening. This drawbar is tensioned with a small coil spring where the drawbar touches the rear of the frame. If any dried oil, dirt, rust, etc prevents the drawbar from going fully forward, it interfers with the hammer motion. Sometimes the small coil spring gets kinked or broken.
The fix is to disassemble, clean, and inspect the action.
Or, if are uncomfortable with removing the sideplate and working on the internals, squirt cleaning solvent into the action, work the cylinder release repeated, and squirt more solvent to rinse and wash out the dirt.
Relubricate, wipe off, and try it again.