I have so many N frames in 45 ACP, I didn't need another gun. So I picked up a Mod 25 ACP cylinder and yoke assembly. I was amazed that it just dropped into my Pre Model 26. And of course I didn't have to alter the frame window lug in the lower right corner of the window because the cyls are the exact same length.
Then I extended the shoulders in the chambers, but not far enough for the 45 Colt cartridges to seat on the rim. I let them stick out .030", the difference between 45 ACP headspace and the normal 45 Colt headspace.
No less safe than shooting 45 ACP since its case head sticks out of the chamber the exact same amount.
Plus it added back the .030" to make the chamber length the same as the S&W short 45 Colt cylinders that handle standard 45 Colt bullets. I never had any trouble finding off the shelf 45 ammo that would fit the cylinder, (when you could buy ammo!) The reamer I used put a nice rounded shoulder (like S&W 45 Colt cyls) for my rd crimped 45 Colt cases.
But mostly I handload, especially for the extra long nose 45 bullets, like the 250 gr Keith bullets. I just deep seat them enough to be flush with the front face of the cyl. I don't 'hotrod' my loads that much and with the right powders, never had a problem with compressed loads. In fact the fuller the load, the better volumetric burning efficiency I get and therefore more consistent groups on target.
I found myself not even changing back to the original ACP cyl to shoot ACP rounds, (just use 1/2 moon and full moon clips, or 45 AR cases.