My first choice would be a Buck Mark (Camper UFX, Practical URX or Standard URX), second a tie between a Ruger Mk IV (standard barrel) & a S&W Victory 22. If you can rent those three at the range, do that & let her decide. I have one Browning, a Plus UDX, which has been accurate and trouble free for 7 years with no mods or upgrades. My wife also has an older Practical, a Plus UDX, and a Medallion: ditto for those guns. She may find the URX grips a bit friendlier than the UFX grips. I like the UDX best, but those go up one price level.
I have an old Ruger Standard (1951), a 50th Anniversary Mark II, and a Mark IV Target. While they all shoot fine, breaking down & reassembling the old Standard and Mark II is still an aggravation compared to the Mark IV. I can have the Mark IV barrel off, bolt out, and ready for cleaning in 5 seconds if I take my time. Same for reassembly. Simply cannot beat that.
The SW22 Victory is also a nice gun, shoots well, has a smaller grip frame that she may prefer, and has "just right" fiber optic sights. The only problem I've had with that was jams caused by the ejector arm/tab being a touch out of alignment. I found the simple fix on this site (see njsarn's post #30 on this thread:
http://smith-wessonforum.com/smith-...-not-ejecting.html?highlight=victory+fte+jams), and it has functioned without trouble ever since.
I would not recommend the Walther P22. We had one a few years back and it was a Jam-O-Matic. Awful little gun. They say it has been improved and current production does not suffer the same problem, but....
Good luck in your search, and remember, it's her gun, so she gets to decide.