I have two 6" Pythons I've owned for a long time. I've fired both extensively but mostly with cast .38 Special loads. I shoot Bullseye style and can't recall ever shooting the Pythons double-action. As for Colt shooting guns, I prefer a couple of 6" .357 models I've also had a long time; they're not muzzle heavy like Pythons and are just as accurate.
Comparing Pythons to S&W 27s or others S&Ws is tough - they're all good guns. I question the alleged fragility of Colts. I haven't seen it, but others claim to have experienced it.
I couldn't imagine buying an older Python these days simply because of the prices. If you want an accurate revolver, you can do at least as well as a Python for a lot less money.
I realize some like to buy guns and put them in a safe for someone else to fight over or sell some day - a sad choice I've never understood, but it's their money and their gun so I suppose it's none of my business.
Maybe I can explain.......Back in the 70s and 80s I bought two pythons, one 6in blue and one 6in stainless. blue one I gave $389.00 the stainless I gave $759.00 two years ago sold em both, blue one sold for $2,500.00 and the stainless one sold for $3,000.00 both new in the box unfired......thats the reason...................................M*