I converted a Model 28-2 from 357 S&W Magnum to 45 ACP. I had the barrel bored and rifled. I fit the new cylinder, frame lug and etc. with time and a file. When the barrel came back, it needed to have one or two additional turns to meet the cylinder. Still did not have a lathe so the shoulder got set back with the same file. Then with the barrel at TDC, I needed to shorten it slightly so the cylinder would close and set the b/c gap. Again, the file.
My point? If you want to do it, you can! It just depends on how ambitious you are or how much money you have.
Go for it!
Kevin