If we are talking about protection of your home (inside the house) then long distance target acquisition is not an issue. In my home, protection of others in the house is my first concern. Keeping in mind that the intruder must be neutralized.
My first choice is my Rem. 870 with low brass 7 1/2 shot, for indoor use. The only reason for a handgun is for low profile and ease of concealed carry. If we must move down to a pistol or revolver then my first choice is Glaser "Blue", for in house use. My best friend is a 30 year nurse who has worked in autopsy and has seen, up close and personal, what this round has done. Having said that, any round placed in the correct location will take a person out. The Glaser "should not" jump from room to room, helping to protect others.
Any other ammo that you may use inside your home, I feel, should be of a type or design that will reduce the probability of over penetration. As we have all been taught, know not only your target but beyond should be known.
Hornady Critical Defense, Magtech, and Cor-Bon I have found to be good reliable ammunition. As you know there are other great rounds out there. It always comes down to what works best in your weapon and for you, you must be comfortable with the ammo. If needed reduced-recoil ammo may be a good choice.
The single most important matter in protecting your home and family is you, staying calm and acquiring your (correct) target. Many of us have had the training but never had to use it. Hope you never have to encounter an intruder. Remember most encounters of this type are less than ten feet.
Good Luck.
