One of my carry pistols is a manual safety 365, and I practice a lot with it, and shoot some competition IDPA events with it. I have shot 1911 pistols for years so have no problem clicking off the safety when I draw my 365. But if a person chooses, they do not have to engage the safety. Just better to always use or never use the safety on the pistol. Mine has never once had a malfunction with my assorted hand loaded ammo or any store bought 9mm. You will need one of several devices to fully load the mags, as the springs are really stout in the mags. There is a good assortment of holsters available for the 365, I prefer a King Tuk or an On Your Six holster, depending on what I am wearing. Going to gear up with my SIG in a few hours for church.. I am on my church's security team. I have big hands, and with the slightly longer magazines available for the 365, I can handle the pistol quite well, much better than some other small guns I have tried to shoot. If you want to practice accurate shooting for fun, they are very accurate pistols if you do your part.
If and when you decide to carry a defensive pistol, like the posters above suggest, shoot it a lot, and get comfortable with drawing it from your holster. And understand clearly the carry laws in your state.
Part of carrying is not just one's firearm, but the choice of holster and gun belt, and making sure the holster's clips fit the width of the gun belt, and your holster securely retains your pistol. Most carry people have a variety of holsters before they find the ones that work best for them. If you have a local gun store, ask about any shooting clubs or teams that they know of, and seek their experience and guidance, you will find them very willing and patient with helping a new shooter learn safe and enjoyable handgun shooting and personal protection.
And while store bought ammo is expensive now, be sure to regularly shoot whatever you decide to carry.
SF VET