There's no danger in shooting any factory ammo or quality handloads with the over-sized throats. Accuracy will be iffy at best, and down right lousy at worst,
With all the current shortages, bullets for handloading, especially in the larger sizes, are very hard to come by. If you can locate any Magtec or Winchester or Remington 250-255 grain swaged lead bullets at a Cabela's or one of the on line sources, they are all larger in diameter and have hollow bases which will slug up (obturate) and seal off the throat which increases accuracy greatly in guns with over sized throats. The Win brand (if you can find any of them) run .456", while the Rem and Magtec run .455". For paper punching, these bullets are all fine and shoot quite well, but if you hunt with your handguns, they are a poor choice.
My 4" 25-5 has correct throats as does my 25-7, but my 25-2 is afflicted with .456" throats, and requires a lot more effort to get it to shoot well.
You would only be able to fit an acp chambered cylinder if you used a 41 or 44 magnum full length non recessed cylinder for the project. Then, the cylinder would have to be reamed and an extractor for a 25-2 located and installed or the one from the doner cylinder would need some machining. In other words, a lot of expense and hassle.
Sorry for the poor picture quality, but these were taken indoors