Okay,we all agree that the 22lr is not a death ray. But in 34 years as an urban, big city cop, i saw about as many, if not more, fatals with a .22 as with any other handgun. Most were head shots within 2 or three feet. The othere were chest shots that missed bone and hit the heart and lungs. Those solids seem to rattle around inside a person for a while. If all I had was a .22, I'd stick it up the bad guy's nose, in his ear, or under his chin pointing up. Still, I'd prefer another caliber.
This is a funny subject; once one of our vice guys, doing the wino-waiting-to-be-robbed thing, was accosted by a thug with a knife, and shot said thug 6 times with a model 29 4". All were CM hits, but the guy lived. No handgun round is more than a convenience.