If all your carry guns have the same manual-of-arms (such as with a revolver, in draw, aim, squeeze), there shouldn't be too much confusion. The four that I regularly carry all operate the same way, just point and shoot, nothing else.
Now, if you throw a gun into the mix with a different MOA, like a 1911 for example, there's potential for confusion under pressure.
I've always found it hard to understand those who vary their EDC guns.
It seems to me as though one would want to stick to the KISS principle when it comes to a weapon that would be called upon when the adrenaline is flowing and the fight or flight syndrome is in full swing.
That said, being an old fart who likes (and I guess needs things to be simple), I carry a J-Frame either in the right front pocket or in a Galco holster on the belt. Even THAT seems to have the potential for unfortunate consequences should I have a brain malfunction and go digging in my trouser pocket when my revolver is on my belt.
Now don't get me wrong, I have other options, including K-frames and several full-size 9 mm pistols. Love to shoot them but I think I'll KISS and stick to the J-Frames for carry.