With the right gun and loads yes.
I guess I already have, actually. I was in NW Colorado last summer, visiting friends at their mountain home, and they are definitely in bear country. Mountain lion country, too - and they see panthers way more than they see bears, but they're around.
I brought my Ruger Service Six with me, and I loaded it with high quality .357 Magnum defensive ammunition that my buddy keeps for his guns (offhand, I forget which brand).
When we were driving out and about I left that gun at the house and carried an easily concealable handgun (CHL reciprocity is a lovely thing) but when we were hanging out at the house that gun was always handy, especially sitting on the veranda sipping adult beverages. It was one of those rare times when despite the presence of alcohol we kept loaded guns handy. We were not getting drunk, anyway, just yakking and enjoying the evening air. But bears and lions have been known to suddenly appear so we had to be prepared.
If I was hunting in bear country I would first be carrying a rifle, I am not into handgun hunting,
per se, but my backup gun (and there would be a backup gun if it was legal) would be either a .357 Magnum or, if I was inclined, a .45 Colt. I can pump out 6 rounds from either of those accurately and way faster than I ever could from a .44 Magnum, which explains why I don't own a .44 Magnum any longer.
But, since this is a bear thread - HANG ON TIGHT!!!!!!!!!!
