Not according to Chris Baker (LuckyGunner). Inadequate penetration from 4-in barrel, and (ironically) slightly better (but not reliably) from a 2-in barrel, owing to less expansion. But as the saying goes "better than nothing".
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Compare to the next step up, Hornady 110-gr FTX Critical Defense:
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I really like the Lucky Gunner videos but there is a problem with depending on these and many other YouTube videos in making a weapon or ammunition choice. Whenever you see an unusual disparity between say a 2" revolver and a 4" revolver you have to also measure the cylinder gap. Barrel wear and brand also comes into play here.
A underperformed 4" might have a huge cylinder gap compared to a new and tight high-end 2". I've seen this sort of result on any number of bullet test videos. Different gaps, makes, barrels and barrel wear makes these comparisons pretty much worthless.
Comparisons between bullet brands or weights through the same weapon on the same day and weather conditions is a reasonable test. As soon as you see a different weapon/ barrel being used it all goes out the window.