It is hard for some people to drop their intuitive feelings and discard incorrect old lore. Yes you, Mr. .45 Cal.
Terminal ballistics studies are showing that velocity over 2,200 fps causes serious damage even with small projectiles. With less velocity shot placement and adequate penetration quickly become paramount.
Pistol calibers are surprisingly similar in lethality.
This understanding of terminal ballistics is a big part of the trend away from heavy revolvers to 10mm pistols in big bear country.
The wild card is the motivation, mental state, adrenalin, drug use, etc. of the target.
2200 fps? Maybe for home defense from a .30 or .223 carbine. (Speer claims 1990 fps for 110 grain, and 3220 fps for 55 grain Gold Dots out of 18" and 22" barrels.) But not from a concealable pistol.
Longer barrel length = more propellant burned = more velocity. Using the same .357 125 grain GDs a 7.5 inch barrel SA revolver supposedly delivers 1307 fps and a 16.5" 1894 1987 fps.
BBI tested 3 loads in a .25 Jetfire 765 -- 800 fps
4 loads in a 32 Tomcat 774 -- 1000 fps
7 loads in a .380 LCP 796 -- 1054 fps
5 loads in a .38 Spl 642 847 -- 940 fps
10 loads in a 3" 9x19 933 -- 1389 fps
8 loads in a 3" .357 1191 -- 1313 fps
(4" 9x19 and .357s were constantly ca. 150 fps higher than a 3," so a 2" would be less by up to a commensurate amount.)
11 loads in a 4" .40 989 -- 1336 fps
10 loads in a 3.75" .45 auto 716 -- 1054 fps
(Those are the smallest .40 and .45s they tested.)
I carry a .357, GDSBs are supposed to deliver 990 fps from 2". One thing about a .45, it's always at least .451" in diameter. Some of the light bullets scoot, and those that travel at 750 fps weigh a lot.