I've used lots of 296 in my Bisley, super Blackhawk and my 29s , I've loaded 26.5 grains of 296 in the ruger Bisley 45 colt and it's a real boomer. I was surprised that Linebaugh uses 26 grains in his model 25. I can see where a steady diet of that load coukd send the gun to the doctor. Well I just loaded 19 grains of 2400, just a handful thst I'll try out this weekend and see how they perform in the accuracy dept. oh yeah I was also surprised at his top load with 2400, 22 grains. I loaded 23 grains with a 240 grain bullet 40 years ago in my ruger 45 colt and model 29. Accuracy seemed to suffer a little but I'm sure most of it was due to me flinching being young and inexperienced . I'll blame those days on Elmer Keith lolI used H110 and 296. I ended up on the lighter side of Linebaugh's listed loads. The upper levels are really stout and I don't see a real need for them unless you're in Grizzly country.
I've also used Ruger only loads found in the Speer manuals. They are lighter than Linebaugh's loads and perform exceptionally well.
A steady diet of these loads will, of course, speed the wear and tear on your weapon. For occasional use they aren't a problem.