Regarding the whole "bear defense" scenario, There's a study that shows a wide variety of handguns being successfully used to stop a bear attack. It seems that being able to get hits quickly and accurately does matter. The study has been posted several times in similar threads here.
This is different from "hunting", where an ethical one-shot kill at longer ranges is desirable.
My opinion (and it is just that, issued from the safety of my armchair), is that any reasonably powerful handgun with the right ammunition that you can use quickly, repeatably, and accurately at short range may be a better choice than something that might work better in a hunting scenario. Each individual must make that choice for themselves.
For me, that would probably mean a Glock Model 20/40 or a Smith and Wesson 686+ (probably four-inch). That's based on MY history of drawing, handling, and shooting long-slide Glocks and L-frames.
Your experience may vary.