Two issues here.
One is that pistol primers are made from slightly thinner metal to more reliably ignite from the relatively lower energy of handgun firing pins compared to rifle firing pins. As a result, pistol primers will fail gas containment (rupture) at somewhat lower pressures than rifle primers.
Second is that pistol primers are thought to contain less priming compound than rifle primers since they usually have less powder to ignite.
On the other hand, there are those who use pistol primers in their target and bench rest loads thinking that the lesser concussion of the pistol primer lends more consistent ignition and less pre-ignition movement of the bullet into the barrel.
That being said, small pistol primers would work in .218 bee--relatively small case, BUT this is not necessarily a low-moderate pressure round just because it is small. Any advantage gained here would be toward consistency and reducing SD for accuracy. No advantage would be gained toward reducing maximum pressure. Instead, the pistol primer would be more likely to rupture. Not a good thing. they are NOT for maximum loads.