Well, I have carried a Combat Commander, 3" 629, a 4" 28, a 3 1/2" 28, a 4" 25 in .45 Colt, a 4" 29-2, a 6" 29, a 6" 629, a 6" 28, a 4" Python, a 4"19, a variety of Glocks, and a 442 on a consistent basis over the years. If I had to stick with one, I wouldn't, but to me the most practical are the Nframe .357s, and believe it or not I'd go with my 5" 27, which doesn't currently get carried much.