.The 10mm does NOT have a safety margin to run up the loads... The .40 case is actually stronger than the 10mm case because of the small primer pocket, thus more meat in the base. The 10mm case is prone to significant bulging in barrels with inadequate chamber support, and this is an impediment to pushing the loading envelope unless you have a fully supported chamber.
As far as "safety margin" goes, short cases filled to capacity with medium/fast powders are more prone to high pressure spikes caused by bullet setback than larger cases that have an air space in them.
Any pistol case in an unsupported chamber will bulge even the 9x19, with its thick tapered walls, if pushed to +P+ territory.
Sounds like you never heard of the Glock smile, infamous on their early 40S&W models with unsupported chambers?
40S&W cases are no stronger than 10Auto cases. If anything the 10Auto cases should be stronger since it operates at a slightly higher max SAAMI pressure, 37.5K psi -vs- 35K psi.
And having small pistol primers means nothing at pistol pressures. The 10Auto cases that have SPP are not any stronger the ones using LPP. It just doesn't matter in this case.
Back in the day they said the 454 Casull had to have SRP to operate safely but it was just the brass' problem. No modern large caliber magnum pistol cartridge since then has used small primers instead of large primers, not the 460 Magnum or the 500 Magnum nor any other common one you can think of. It's a non-issue with modern brass designed & manufactured properly.
It's not the cartridge's fault that some manufacturers design their firearms with unsupported chambers. Definitely not going to see any 460 Rowland barrels with unsupported chambers.

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