I wouldn't depend on a 410 as much as a 45 unless maybe it was across a regular sized room. I don't think that it would do anymore damage than a 45 inside that room either and accuracy would still be needed. 3 pieces of 00 buck? even with smaller shot your not putting out more lead than a 45 slug. I don't believe it is a superior to a decent handgun under any defense situation. Sorry, but, to me the the Governor and it clones are only interesting novelties. They will work, but, have you ever heard of a police or military organization opting for a 410 under any circumstances? 410 is for rabbits, doves, rats etc. It will work for other stuff, but then a 22 will kill a bear too, just not going to be my first choice.
No, I don't want to be shot with one, or a 22 short either, pellet guns are also off my want to be shot with list.