A single hit is worth any number of misses.
And it doesn't make a particle of difference what round is used.
A .22 rf, .25acp, .32acp, a .380, or a slow lead.38 sp. wadcutter. through a tender spot (like the BG's face) will get the message across, and may take all the fight out of him. 2 or 3 similar hits may confirm it. Rat/snake shot will slow 'em down quite a bit as well, but it won't make a big bloody wound channel, and won't dispatch 'em permanently.
A defensive shooting ought to be convincing at least, if not deadly.
I load 148gr. hollow base wadcutters for all the .38 specials on the pile. They are not really stout, but they handle well. There was some talk a while back about HBWC loaded backwards to create a cup-point. Like a flyin' ashtray at about 800-900fps.
My loads handle nearly the same as the Federal Nyclad HPs. I have some of those in 125, 148, & 158 gr. I haven't seen any on the shelf around here for ages.