I view 'bedside guns' much as I do 'truck guns'....
.
Reason being, as a Detective assigned to Residential Burglary for about 10 years, can tell you that when a B&E occurs in your absence (which is about 98% of when all burglaries happen), one of the first places checked/ransacked is your bedroom in a search for the ever-present firearms and/or jewelry.
Next - is the nearby master bathroom medicine cabinet for drugs.
All easily found, easily concealed, and easily moved for drug money.
So, with this in mind my 'bedside hardware' resembles what I'd use in a 'truck gun' role - reliable, dependable, not too expensive and easily replaced.
My side - a Taurus PT92 9mm with several loaded mags nearby.
Wife's side - Taurus SS Judge with first 3 rounds .410 PDX Defender rounds, last two Keith 255 gr LSWC.
Neither of these are anything great - but both work fine and if stolen (which I hope never happens), we've lost nothing of heirloom quality and replacement would not be difficult.