shouldazagged
Absent Comrade
Seems nearly all the responders assume an autoloader is the best solution. Many women can quite comfortably and effectively shoot revolvers in .38 Special or .32 H&R Magnum, without worries about racking slides, failures to feed, limp-wristing, etc. Sure, a .22LR beats no gun, but the faithful old revolver still works damn well.
And ultimately, as has been said before, it has to come down to what the OP's wife is comfortable shooting.
And ultimately, as has been said before, it has to come down to what the OP's wife is comfortable shooting.