Most home robberies are snatch and grab jobs. Meaning, the thieves are in and out in less than 10 minutes. Most are not going to spend the time or effort to try and pry open a safe or remove it from the home. Think about it. Even if they could get it out (which would take some considerable time and prep) do you think they want to be seen by your neighbors loading it into the back of their van or truck?
Most quality safes (liberty, cannon, ect.) have min 30 minutes for a fire rating. Unless you live in BFE you should be ok. Most of us will have the FD show up long before the room the safe is in reaches those kinds of temps to destroy whatever is inside.
Quality safes have a great deal of structural integrity. With internal hinges and multiple locking bolts on 1 – 4 sides an ill prepared thief will take hours trying to get into most quality safes. That's provided he can find the right tools. Like I stated before most won't mess with it. Too much effort, time, and noise.
Regarding the locking up of ammo, I do it too. My first reason is safety. In the event I do have a fire my safe is the best place for it because of the 1 hour fire rating. Second in the event a round does go off it will have to penetrate the ammo can and steel safe to become a threat to anyone. Third, I don't want any kids at my house to snatch a bullet and take it to school to show their friends. That's serious trouble for me and them. BTW, all my dangerous stuff is locked up too. ie, explosives, drain cleaners, paints, knives, ect.
In conclusion here is my take on safes. If you own multiple guns you should own one. By not having one you are making yourself more vulnerable to theft and potentially providing the far left more ammo (no pun intended) to push gun control. Where do you think criminals get their guns? By breaking into homes and stealing them. You can never fully protect your gun collection however you can make it so difficult that no one will ever want to attempt to steal it. Start small and work up to a more secure storage system as your collection grows. If you have the means hide the safe. The best way to store your guns or any valuables for that matter is to hide them. Out of sight is out of mind.
BTW, dig the inventiveness of the velcro. I had to do the same thing but chose to secure holsters to the inside of the door with screws covered in felt. Works well for now.