Since the late 60's, I've ridden everything from H-D, Kawasaki, Honda, Cagiva, KTM, Husqvarna, Benelli and probably a few I've forgotten. From full-dress Harleys to crotch-rockets. I actually prefer the crotch-rockets.
As one or two others have said, I never rode more than about 60 miles on the H-D without stopping to rest, and I got off feeling like I'd done 12 rounds with Rocky.
I have been out of bikes for about 10 years now, but if I were to get back, the Gold Wing would be my choice for distance or mid-length rides, hands down. Ride all day as comfortably as sitting in a car.
For a cruiser only, I still wouldn't take a Harley, it would be a Victory.
For carving twisty's, on places like the Tail of the Dragon and other local rides, the H-D's are so hideously out of place it is pathetic. A crotch-rocket is the only way to go. Honda, Kawasaki, and Ducati all make great ones. Suzuki probably still has the fastest, the Hayabusa, but I never really cared for the brand.
So, my recommendation is to look at the type riding you want to do and choose accordingly.
For a wonderful, safe, reliable bike that can cruise and carve...look at the BMW lineup. Just like their cars, they really are amazing machines.
The Highlander