Premise #1 - The * Canister * grade powders that were around back in the day, that are still with us , are Reasonably Close to their properties back then .( Insert a cpl off the top of my head w/ small variations over the years, and undoubtedly others .)
Premise # 1.5 - If an Historic Powder was a good choice for a particular load catagory in Historic Cartridge back in the day , it's probably just as good today .
Premise #2 - If we're speaking of Factory Loads , the abovementioned doesn't mean much . Major Ammo Mfg have always had access to , and probably primarily used NON-Canister powders, either straight from Powder Mfg , or custom blended by Ammo Mfg . That's why Ammo Mfgs employ Chemists , and Chemical Engineers . Various Factory loads in different eras were/ are impossible to duplicate with Canister Powders .
Premise #3 - There are Whole Buncha powders available in the Modern Era that can do wonderful things , beyond the comparitive hand full of powders available in pre WW II era . Either match classic load at lower pressure/ more consistent/ cleaner , or safely achieve higher safe velocities than were possible back in the day . Off the top of my head ; in various combos load catagories that were once the domain of 2400 and 4227 , now also have Lil Gun, AA9 , 296/H110 , H108, N110, and more, and their closely related non- cannister variants . Heavy loads of Unique are be duplicated with higher Vels And lower Pressures by Power Pistol .
Premise # 3.5 - Some of the Classic Factory, and Iconic Handloads , may well have been at the optimum velocity levels of effectiveness vs control , but cleaner, or consistent, and/ or lower pressure are good things .